Here is Dr. Andelfinger’s academic background:
- MD from the University of Ulm (Germany)
- Pediatric specialty at the University of Geneva
- Training in Cardiovascular Genetics at the Cincinnati Children’s Hospital
- Training in Molecular Cardiovascular Biology at the IRCM, Montréal.
His research focuses on human genetics of cardiac malformations and the developmental biology of the cardiovascular system. Questions that are raised through it are:
- Why are some children born with cardiac malformations?
- Why are there families with several cases of cardiac malformations?
Over the past decade, knowledge of the molecular cascades that regulate the development of the heart increased, as well as the development of new tools for genetic analysis of families with multiple affected members.
Since 2006, Dr. Andelfinger has established the first Canadian biobank specifically geared towards the investigation of the genetics of congenital heart disease in a province-wide effort. Together with other renowned researchers, they have found the genetic origin of a certain percentage of a dangerous form of heart deformities, focusing on the changes in the number of copies of rare genes involved in the development of the disease. By identifying them, it is possible to develop better diagnostic strategies and therapeutic stratification for patients with congenital heart disease.
You remember Sabrina, a young girl afflicted with two specific diseases, one that dangerously reduces her heart rate and one that affects the intestines that we call intestinal pseudo-obstruction? Dr. Andelfinger, together with a team of researchers including Dr. Philippe Chetaille, are also working on an international research project about this orphan disease. Sabrina, like many other children, wishes with all their hearts that the best researchers are finding solutions to their problems!
To know more about the children, like Sabrina, who are supported by research, click here